Faster Cache-Efficient Pattern Matching for Deterministic Wheeler Pangenome Graphs

Pattern matching on strings is regarded as one of the core operations in computer science. Although many solutions have been proposed for this problem, some of the most elegant and widely used approaches are based on the renowned Burrows-Wheeler transform (BWT). The success of the BWT lies in its pattern matching algorithm known as backward search, which is not only near-optimal in the RAM model, but also runs directly on a compressed representation of the input string. More recently, this backward search has been generalized to Wheeler deterministic finite automata (DFAs), a subclass of standard DFAs, without losing its near-optimal time efficiency. Similarly to the case of strings, this pattern matching algorithm for Wheeler DFAs has found applications in bioinformatics, where researchers have shown that specific pangenome graphs of human chromosomes can be transformed into Wheeler DFAs and consequently indexed using this strategy. However, this BWT-based index on Wheeler DFAs inherited a significant drawback from the original backward search, namely the high number of I/O operations triggered during the algorithm execution, which are in the worst-case lower-bounded by the length of the pattern. In this paper, we address this limitation by proposing the first cache-friendly algorithm specifically designed for Wheeler DFAs. Our new data structure reduces the number of I/O operations by employing a strategy analogous to the suffix array: it interleaves a binary search with fast sequential scans of the automaton. We empirically validate this new indexing strategy by running our algorithm on real-world Wheeler pangenome graphs. We show that while our data structure can use up to 15 times the space required by the backward search index, it can also be 500 times faster and able to process a single character of the pattern in less than 3 ns.