A conjugate which is capable of specific binding to and inhibition of urokinase-type plasminogen activator (UPA) comprising a polypeptide molecule and a scaffold molecule, wherein said polypeptide molecule is attached to said scaffold molecule by at least three covalent bonds and wherein the inhibition constant (Ki) for said inhibitor is less than 500 nM.
La presente invenzione ha per oggetto derivati peptidici biciclici ottenuti coniugando ad uno “scaffold” di sintesi organica sequenze peptidiche lineari derivate. I composti dell’invenzione presentano elevata potenza di inibizione dell'attivatore del plasminogeno di tipo urochinasi umana.
A determination method of determining optimal routes for navigating naval vehicles by analysis of historical GNSS data, which optimal routes consist of sequences of waypoints. The determination method comprises the steps of: reducing the data by using an extraction method to retain only significant positions of a trajectory while keeping information about speed and heading changes; evaluating trajectories similarity by using a distance measure; applying a clustering algorithm to verify whethe...
A solid state switching device, such as a solid state circuit breaker, includes at least one heat sink, a control electronics printed circuit board (PCB), and power electronics. The power electronics are useful to regulate the flow of current from one terminal of the solid state switching device to another terminal. The power electronics can include one or more solid state devices such as FETs, Thyristors, Thyristors+ SiC JFET in parallel, IGBTs, and IGCTs. The control PCB can include a varie...
A solid state switching device, such as a solid state circuit breaker, includes at least one heat sink, a control electronics printed circuit board (PCB), and power electronics. The power electronics are useful to regulate the flow of current from one terminal of the solid state switching device to another terminal. The power electronics can include one or more solid state devices such as FETs, Thyristors, Thyristors+ SiC JFET in parallel, IGBTs, and IGCTs. The control PCB can include a varie...