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Recent Advances in Bioconjugated Transition Metal Complexes for Cancer Therapy

The introduction of biologically relevant organic moieties in the coordination sphere of transition metal complexes has recently become a well-established strategy to increase the selectivity and biocompatibility of metallodrugs. In this review, the major advances achieved in this area of research in the last three years are described in detail. Particular attention is given to the metal complexes bearing the main biomolecules of life: carbohydrates, lipids, nucleotides, proteins and vitamins...

Combined Treatment of Cancer Cells Using Allyl Palladium Complexes Bearing Purine-Based NHC Ligands and Molecules Targeting MicroRNAs miR-221-3p and miR-222-3p: Synergistic Effects on Apoptosis

Combined treatments employing lower concentrations of different drugs are used and studied to develop new and more effective anticancer therapeutic approaches. The combination therapy could be of great interest in the controlling of cancer. Regarding this, our research group has recently shown that peptide nucleic acids (PNAs) that target miR-221 are very effective and functional in inducing apoptosis of many tumor cells, including glioblastoma and colon cancer cells. Moreover, in a rece...

L’apocalittica dopo il Tempio. Il Quarto libro di Esdra (4 Esdra).

Secondo Neemia 8, Ezra avrebbe istituito per mandato del popolo la lettura e spiegazione pubblica della Legge. Per il giudaismo posteriore, e in particolare per la sua versione farisaica e poi rabbinica, egli divenne quindi una figura pressoché mitica di nuovo Mosè e maestro della Legge, e gli fu pseudepigraficamente attribuita la stesura di una nutrita serie di libri. Tra questi, l’ampia apocalisse intitolata Quarto libro di Esdra (o 4 Esdra) è il primo in cui Esdra viene rappresentato prin...

Lifting restrictions with changing mobility and the importance of soft containment measures: A SEIRD model of COVID-19 dynamics

This paper estimates a SEIRD (susceptible-exposed-infectedrecovered-deaths) epidemic model of COVID-19, which accounts for both observed and unobserved states and endogenous mobility changes induced by lockdown policies. The model is estimated on Lombardy and London – two regions that had among the worst outbreaks of the disease in the world – and used to predict the evolution of the epidemic under different policies. We show that policies targeted also at mitigating the probability of contag...

“…NON AVEVA IL SESSO RICOPERTO DAL MUSCHIO” La raccolta collettanea Ani labuť ani Lůna (1936) e la critica sul Diario del 1835 di K. H. Mácha come manifesto estetico, etico e filosofico dei surrealisti cechi

The paper aims to investigate the Surrealist interpretations of the poet Karel Hynek Mácha (1810- 1836), proposed in the collective volume Ani labuť ani Lůna (Nor the Swan nor the Moon, 1936). Published with a clear polemical intention, it contains numerous criticisms of the official celebrations for the centenary of Mácha’s death: a mythologized image of the author, canonized as “the” Czech romantic poet par excellence, poet of love as well as patriot. The Surrealists propose, instead, a...

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