The interactions of the antifouling compound Sea-Ninetwith rat liver mitochondria have been studied. The results indicate that low doses of this compound inhibit adenosine 59-triphosphate (ATP) synthesis. Further investigations indicate that ATP synthesis inhibition should be due to an interaction of Sea-Nine with the succinic dehydrogenase in the mitochondrial respiratory chain.
An in vitro study of the interaction of Sea-Nine with rat lever mitochondria
BRAGADIN, Marcantonio;PAVONI, Bruno;MANENTE, Sabrina
2005-01-01
Abstract
The interactions of the antifouling compound Sea-Ninetwith rat liver mitochondria have been studied. The results indicate that low doses of this compound inhibit adenosine 59-triphosphate (ATP) synthesis. Further investigations indicate that ATP synthesis inhibition should be due to an interaction of Sea-Nine with the succinic dehydrogenase in the mitochondrial respiratory chain.
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