In this work, we present the first results obtained for the electroanalytical determination of Cannabidiol (CBD), the major non-psychoactive cannabinoid of Cannabis sativa L. plant, and Cannabinol (CBN). To this purpose, Sonogel-Carbon-PEDOT material was employed due to the high conductivity provided by poly-(3,4-ethylenedioxythiophene) (PEDOT) combined with graphite powder. Electrochemical measurements were performed in different aqueous buffered solutions mixed with acetonitrile or ethanol to improve the solubility of the analyte. In particular, the ethanol/borate buffer solution 15:85 (v/v) provided a higher electrochemical response of CBD as well as a lower potential peak value. CBD was assayed in a concentration range from 1.59 to 19.1 μM, obtaining high sensitivity, 421 ± 26.1 μA/mM·cm2 and low detection limit, 0.94 μM. CBN was also assayed, from 1.61 to 25.8 μM, obtaining 588 ± 13.6 μA/mM·cm2 as sensitivity and 1.29 μM as limit of detection. Based on the experimental results, the electroanalytical method developed represents a tool for the rapid determination of these types of cannabinoids

Fast electroanalytical determination of Cannabidiol and Cannabinol in aqueous solution using Sonogel-carbon-PEDOT devices

Zanardi, Chiara;
2020-01-01

Abstract

In this work, we present the first results obtained for the electroanalytical determination of Cannabidiol (CBD), the major non-psychoactive cannabinoid of Cannabis sativa L. plant, and Cannabinol (CBN). To this purpose, Sonogel-Carbon-PEDOT material was employed due to the high conductivity provided by poly-(3,4-ethylenedioxythiophene) (PEDOT) combined with graphite powder. Electrochemical measurements were performed in different aqueous buffered solutions mixed with acetonitrile or ethanol to improve the solubility of the analyte. In particular, the ethanol/borate buffer solution 15:85 (v/v) provided a higher electrochemical response of CBD as well as a lower potential peak value. CBD was assayed in a concentration range from 1.59 to 19.1 μM, obtaining high sensitivity, 421 ± 26.1 μA/mM·cm2 and low detection limit, 0.94 μM. CBN was also assayed, from 1.61 to 25.8 μM, obtaining 588 ± 13.6 μA/mM·cm2 as sensitivity and 1.29 μM as limit of detection. Based on the experimental results, the electroanalytical method developed represents a tool for the rapid determination of these types of cannabinoids
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10278/3755508
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