A straightforward synthetic route to a selection of new ferrocenyl complexes bearing different organopalladium fragments is reported. The target complexes were fully characterized by Nuclear Magnetic Resonance, High Resolution Mass Spectrometry, Infrared Spectroscopy, X-ray Diffraction, and electrochemical techniques. All compounds, with the exception of Pd(0)-olefin derivatives, showed excellent antitumor activity on ovarian cancer cells and, in the case of Pd (II)-allyl and Pd (II)-butadienyl complexes, a lower cytotoxicity towards normal cells.

Synthesis, characterization, and anticancer activity of ferrocenyl complexes bearing different organopalladium fragments

Scattolin T.;Guadagnin Pattaro A.;Rizzolio F.
;
Bortolamiol E.;Moretto L. M.;Visentin F.
2022

Abstract

A straightforward synthetic route to a selection of new ferrocenyl complexes bearing different organopalladium fragments is reported. The target complexes were fully characterized by Nuclear Magnetic Resonance, High Resolution Mass Spectrometry, Infrared Spectroscopy, X-ray Diffraction, and electrochemical techniques. All compounds, with the exception of Pd(0)-olefin derivatives, showed excellent antitumor activity on ovarian cancer cells and, in the case of Pd (II)-allyl and Pd (II)-butadienyl complexes, a lower cytotoxicity towards normal cells.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in ARCA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10278/3752656
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact