An alternative approach is reported for the synthesis of methyl ester protected bisphosphonate building blocks, such as methylene bisphosphonate, vinylidenebisphosphonate and aryl substituted prochiral vinylidenebisphosphonates, that cannot be obtained directly from dimethyl phosphite and dichloromethane.
Challenging synthesis of bisphosphonate derivatives with reduced steric hindrance
Chiminazzo, AndreaFormal Analysis
;Sperni, LauraFormal Analysis
;Fabris, FabrizioWriting – Review & Editing
;Scarso, Alessandro
Project Administration
2021-01-01
Abstract
An alternative approach is reported for the synthesis of methyl ester protected bisphosphonate building blocks, such as methylene bisphosphonate, vinylidenebisphosphonate and aryl substituted prochiral vinylidenebisphosphonates, that cannot be obtained directly from dimethyl phosphite and dichloromethane.
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2021TethraedronLetters.pdf
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