An alternative approach is reported for the synthesis of methyl ester protected bisphosphonate building blocks, such as methylene bisphosphonate, vinylidenebisphosphonate and aryl substituted prochiral vinylidenebisphosphonates, that cannot be obtained directly from dimethyl phosphite and dichloromethane.

Challenging synthesis of bisphosphonate derivatives with reduced steric hindrance

Chiminazzo, Andrea
Formal Analysis
;
Sperni, Laura
Formal Analysis
;
Fabris, Fabrizio
Writing – Review & Editing
;
Scarso, Alessandro
Project Administration
2021

Abstract

An alternative approach is reported for the synthesis of methyl ester protected bisphosphonate building blocks, such as methylene bisphosphonate, vinylidenebisphosphonate and aryl substituted prochiral vinylidenebisphosphonates, that cannot be obtained directly from dimethyl phosphite and dichloromethane.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10278/3739482
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