To survive, an informational macromolecule must solve the major problem set by its very polymeric nature: instability. This is especially true in prebiotic terms because of the presumed initial absence of protective structures (proteins, lipids, etc.). We have analyzed the stability of the β-glycosidic and of the 3′- and 5′-phosphoester bonds in both deoxy monomers and deoxy oligomers under a large set of conditions. The results show a strong dependence of the relative stability of these bonds on the physico-chemical environment. A set of conditions has been identified in which the stability of polymers becomes comparable with that of the precursor monomers. In certain instances the stability of the 5′-phosphoester bond is even higher in the polymer than in the mononucleotide. © 2005 by The American Society for Biochemistry and Molecular Biology, Inc.
|Data di pubblicazione:||2005|
|Titolo:||Origin of informational polymers: Differential stability of 3′-and 5′-phosphoester bonds in deoxy monomers and oligomers|
|Rivista:||THE JOURNAL OF BIOLOGICAL CHEMISTRY|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1074/jbc.M504537200|
|Appare nelle tipologie:||2.1 Articolo su rivista |