The reaction of lithium trimethylsilyldiazomethane [TMS(Li)N-2] with uracil and uridine derivatives is reported; this provides a general method for the synthesis of several new annulated and fused heterocyclic systems. The unexpected cycloaddition of diazomethane (CH2N2) to the C-5,6 double bond of 5-nitrouracil and 5-nitrouridine derivatives is also reported.
Reactivity of lithium trimethylsilyldiazomethane and diazomethane toward the 5,6-double bond of uracil and uridine derivatives
CRESTINI C;
1997-01-01
Abstract
The reaction of lithium trimethylsilyldiazomethane [TMS(Li)N-2] with uracil and uridine derivatives is reported; this provides a general method for the synthesis of several new annulated and fused heterocyclic systems. The unexpected cycloaddition of diazomethane (CH2N2) to the C-5,6 double bond of 5-nitrouracil and 5-nitrouridine derivatives is also reported.File in questo prodotto:
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