The ozonation of 4-thiopyrimidine and 6-thiopurine nucleosides in presence of amines afforded selectively and under mild experimental conditions several cytidine and adenosine nucleosides. The same reaction carried out in presence of alcohols afforded O-4- or O-6-alkylated derivatives of the nucleosides.
OZONATION OF THIONUCLEOSIDES - A NEW CHEMICAL TRANSFORMATION OF 4-THIOURACIL AND 6-THIOGUANINE NUCLEOSIDES TO CYTOSINE AND ADENOSINE COUNTERPARTS
CRESTINI, Claudia;
1995-01-01
Abstract
The ozonation of 4-thiopyrimidine and 6-thiopurine nucleosides in presence of amines afforded selectively and under mild experimental conditions several cytidine and adenosine nucleosides. The same reaction carried out in presence of alcohols afforded O-4- or O-6-alkylated derivatives of the nucleosides.
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