The synthesis of 4-isobutylbenzaldehyde, a valuable precursor for the fragrance Silvial® (3-(4-isobutylphenyl)-2-methylpropanal), is reported. Three different synthetic approaches are reported starting either from 4-isobutylbenzoic acid (via benzyl alcohol, or via acyl chloride), or by Suzuki-Miyaura cross-coupling reaction between 4-bromobenzaldehyde and 2-methylpropylboronic acid.

Synthesis of 4-Isobutylbenzaldehyde an Important Intermediate for the Fragrance (+)- and (-)-Silvial®

BEGHETTO, Valentina;MATTEOLI, Ugo;SCRIVANTI, Alberto;BERTOLDINI, Matteo
2012-01-01

Abstract

The synthesis of 4-isobutylbenzaldehyde, a valuable precursor for the fragrance Silvial® (3-(4-isobutylphenyl)-2-methylpropanal), is reported. Three different synthetic approaches are reported starting either from 4-isobutylbenzoic acid (via benzyl alcohol, or via acyl chloride), or by Suzuki-Miyaura cross-coupling reaction between 4-bromobenzaldehyde and 2-methylpropylboronic acid.
2012
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10278/37056
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