A new catalytic synthesis of Cyclamen-aldehyde (3-(4-isopropylphenyl)-2-methylpropanal) has been developed. The devised synthetic approach entails as the key step the asymmetric hydrogenation of (E)-3-(4- isopropylphenyl)-2-methyl acrylic acid which has been carried out with ees of about 60% by using a catalytic system prepared by combining in situ [Ru(C6H6)Cl2]2 and (S)-MeO-BIPHEP.
Asymmetric catalysis in fragrance chemistry: a new catalytic approach to non racemic Cyclamen-aldehyde
BEGHETTO, Valentina;MATTEOLI, Ugo;SCRIVANTI, Alberto;BERTOLDINI, Matteo
2012-01-01
Abstract
A new catalytic synthesis of Cyclamen-aldehyde (3-(4-isopropylphenyl)-2-methylpropanal) has been developed. The devised synthetic approach entails as the key step the asymmetric hydrogenation of (E)-3-(4- isopropylphenyl)-2-methyl acrylic acid which has been carried out with ees of about 60% by using a catalytic system prepared by combining in situ [Ru(C6H6)Cl2]2 and (S)-MeO-BIPHEP.
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