Bisphosphonates, particularly those with N-substituted groups, are currently the most popular drugs for the treatment of osteoporosis. However, their chemical structures are still rather simple and new synthetic methods are needed to expand their molecular complexity and also improve their specificity of action towards other targets as anticancer, antibacterial, and antimalarial drugs. Herein, we report a new class of potential antiresorption bisphosphonate drugs that have a pyrrolidine unit with different substituents, obtained through a simple dipolar cycloaddition reaction between azomethine ylides and vinylidenebisphosphonate derivatives as precursors. The methodology led to the efficient preparation of a wide range of (1-methylpyrrolidine-3,3-diyl)bis(phosphonic esters) derivatives with different substituents in position 4.
|Titolo:||Pyrrolidine-Containing Bisphosphonates as Potential Anti-Resorption Bone Drugs|
|Autori interni:||DE LUCA, LORENA|
|Data di pubblicazione:||2017|
|Rivista:||CHEMISTRY-A EUROPEAN JOURNAL|
|Appare nelle tipologie:||2.1 Articolo su rivista |
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|2017ChemEurJ.pdf||Documento in Post-print||Accesso chiuso-personale||Open Access dal 20/03/2019|