Micellar Promoted Multi-Component Synthesis of 1,2,3-Triazoles in Water at Room Temperature

Micellar media in water provide a simple and efficient environment to favor the multi-component synthesis of 1,2,3-triazoles from organic bromides, sodium azide and terminal alkynes in the presence of [Cu(IMes)Cl] 1 catalyst at room temperature within few hours. The micellar medium favors both the in situ formation of the organic azide and its metal promoted cycloaddition with the alkyne

Micellar media in water provide a simple and efficient environment favoring the multi-component synthesis of 1,2,3-triazoles from organic bromides, sodium azide and terminal alkynes in the presence of [Cu(IMes)Cl] 1 catalyst at room temperature within a few hours. The micellar medium favors both the in situ formation of the organic azide and its metal promoted cycloaddition with the alkyne.