Encapsulation of a cationic carbodiimide condensing agent within a self-assembled hexameric capsule made of resorcin[4]arene units provides a nano-environment that efficiently steers the substrate selectivity in the amide synthesis reaction between carboxylic acids and primary amines. While in solution pairs of acids react similarly with a given amine, in the presence of the capsule the formation of the shorter amide is greatly favored.

Substrate selective amide coupling driven by encapsulation of a coupling agent within a self-assembled hexameric capsule

LA SORELLA, GIORGIO;SPERNI, Laura;STRUKUL, Giorgio;SCARSO, Alessandro
2015

Abstract

Encapsulation of a cationic carbodiimide condensing agent within a self-assembled hexameric capsule made of resorcin[4]arene units provides a nano-environment that efficiently steers the substrate selectivity in the amide synthesis reaction between carboxylic acids and primary amines. While in solution pairs of acids react similarly with a given amine, in the presence of the capsule the formation of the shorter amide is greatly favored.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10278/3627901
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