The Se-75 internal bioavailability was investigated in microalgae, mussels and rats as biological experimental models. The Se-75 accumulation from freshwater to microalgae [Scenedesmus obliquus (Turpin) Kutzing], from freshwater to mussels (Unio mancus Lamark) and, finally, per os to rats (Rattus norvegicus Berkenhout) was followed using Se-75-labelled selenite looking at Se-75 uptake, retention, intracellular distribution and binding with cellular biocomplexes. After exposure to 10, 50 and 500 mu g Se L-1, the microalgae showed an inhibitory effect on population growth only at the highest concentration. Mussels exposed to 105 mu g Se L-1 showed an accumulation of the element with time in all tissues. Intracellularly, Se was present in all subcellular fractions, especially in the cytosol. Rats were treated via oral administration with 5 mu g Se rat(-1). After 24 h, liver and kidney showed the highest Se concentration.
|Titolo:||Uptake from Water, Internal Distribution and Bioaccumulation of Selenium in Scenedesmus obliquus, Unio mancus and Rattus norvegicus: Part A|
|Data di pubblicazione:||2015|
|Appare nelle tipologie:||2.1 Articolo su rivista |
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