Dimethylcarbonate (DMC), an environmentally friendly substitute for dimethylsulfate and methyl halides in methylation reactions, is also a very selective reagent. Under batch conditions, with potassium carbonate as the catalyst, the reactions of DMC, used as the solvent of the reactions, with methylene-active compounds (arylacetonitriles and arylacetoesters, aroxyacetonitriles and methyl aroxyacetates, benzylaryl- and alkylaryl-sulfones) produce monomethylated derivatives, with a selectivity not previously observed (i.e., >99%). These are examples of "green chemistry".

Selective monomethylation reactions of methylene-active compounds with dimethylcarbonate. An example of clean synthesis

TUNDO, Pietro
2000-01-01

Abstract

Dimethylcarbonate (DMC), an environmentally friendly substitute for dimethylsulfate and methyl halides in methylation reactions, is also a very selective reagent. Under batch conditions, with potassium carbonate as the catalyst, the reactions of DMC, used as the solvent of the reactions, with methylene-active compounds (arylacetonitriles and arylacetoesters, aroxyacetonitriles and methyl aroxyacetates, benzylaryl- and alkylaryl-sulfones) produce monomethylated derivatives, with a selectivity not previously observed (i.e., >99%). These are examples of "green chemistry".
2000
72
File in questo prodotto:
File Dimensione Formato  
PAC2000.pdf

accesso aperto

Tipologia: Documento in Post-print
Licenza: Accesso gratuito (solo visione)
Dimensione 28 kB
Formato Adobe PDF
28 kB Adobe PDF Visualizza/Apri

I documenti in ARCA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10278/31442
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact