A series of nanoporous silica matrices (a silica gel matrix and two ordered mesoporous silica) have been investigated as potential carriers for the controlled release of metoporolol tartrate a selective β1 receptor blocker used in the treatment of several diseases of the cardiovascular system. Particular attention was devoted to the optimization of a reproducible and fast synthetic procedure. The morphology, structure and chemical nature of the porous surfaces were characterized by N2 physisorption, X-ray diffraction, HR-TEM and FT-IR analyses. The delivery profiles were collected in vitro in physiological solution a pH 7.4. We have observed a close correlation between the drug release kinetic and the textural properties of the carriers in particular with their pore size dimension.

Controllled release of metropolol tartrate from nanoporous silica matrices

GHEDINI, Elena;SIGNORETTO, Michela;PINNA, Francesco;
2010

Abstract

A series of nanoporous silica matrices (a silica gel matrix and two ordered mesoporous silica) have been investigated as potential carriers for the controlled release of metoporolol tartrate a selective β1 receptor blocker used in the treatment of several diseases of the cardiovascular system. Particular attention was devoted to the optimization of a reproducible and fast synthetic procedure. The morphology, structure and chemical nature of the porous surfaces were characterized by N2 physisorption, X-ray diffraction, HR-TEM and FT-IR analyses. The delivery profiles were collected in vitro in physiological solution a pH 7.4. We have observed a close correlation between the drug release kinetic and the textural properties of the carriers in particular with their pore size dimension.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10278/29737
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