Aliphatic and aromatic 1,4-bifunctional compounds bearing a primary alcoholic function and an amine can be efficiently cyclised with dimethyl carbonates in the presence of a base to achieve 5-membered N-heterocyclic compounds. This novel synthetic pathway is quantitative, one-pot and green as it does not involve the use of chlorine solvents or reagent.

5-Membered N-heterocyclic compounds by dimethyl carbonate chemistry

ARICO', Fabio;TUNDO, Pietro
2012-01-01

Abstract

Aliphatic and aromatic 1,4-bifunctional compounds bearing a primary alcoholic function and an amine can be efficiently cyclised with dimethyl carbonates in the presence of a base to achieve 5-membered N-heterocyclic compounds. This novel synthetic pathway is quantitative, one-pot and green as it does not involve the use of chlorine solvents or reagent.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10278/28641
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