We report here the first example of peptide-functionalized gold nanoparticles hydrolytically active against carboxylate esters. The active units are constituted by His-Phe-OH terminating thiols. The confinement of the catalytic units in the monolayer covering the nanoparticles triggers a cooperative hydrolytic mechanism operative at pH < 7 in which a carboxylate and an imidazolium ion act as general base and general acid, respectively. Such a mechanism is absent with an analogous monomeric dipeptide, and this results in a more than 300-fold rate acceleration of the hydrolytic process at low pH in the presence of the functional nanoparticles.
|Titolo:||Carboxylate-Imidazole Cooperativity in Dipeptide-functionalized Gold Nanoparticles with Esterase-like Activity|
|Data di pubblicazione:||2005|
|Appare nelle tipologie:||2.1 Articolo su rivista |
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|2005_Jacs_Pasquato.pdf||Documento in Post-print||Accesso chiuso-personale||Riservato|