A novel method for the synthesis of new highly functionalized cyclotrimers is described. The method consists of an original synthesis of ‚-dibromosubstituted pyrroles, metalation, cycloaddition, and cyclotrimerization. The sequence is highly compatible with common functional groups and allows the construction of cup-shaped molecules functionalized both at the upper and bottom rim. This feature makes the newly formed structures useful scaffolds for the development of supramolecular receptors.
Autori: | |
Data di pubblicazione: | 2005 |
Titolo: | The Pyrrole Approach toward the Synthesis of Fully Functionalized Cup-Shaped Molecules |
Rivista: | ORGANIC LETTERS |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/ol047569f |
Volume: | 7 |
Appare nelle tipologie: | 2.1 Articolo su rivista |
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