A novel method for the synthesis of new highly functionalized cyclotrimers is described. The method consists of an original synthesis of ‚-dibromosubstituted pyrroles, metalation, cycloaddition, and cyclotrimerization. The sequence is highly compatible with common functional groups and allows the construction of cup-shaped molecules functionalized both at the upper and bottom rim. This feature makes the newly formed structures useful scaffolds for the development of supramolecular receptors.
The Pyrrole Approach toward the Synthesis of Fully Functionalized Cup-Shaped Molecules
FABRIS, Fabrizio;DE LUCCHI, Ottorino
2005-01-01
Abstract
A novel method for the synthesis of new highly functionalized cyclotrimers is described. The method consists of an original synthesis of ‚-dibromosubstituted pyrroles, metalation, cycloaddition, and cyclotrimerization. The sequence is highly compatible with common functional groups and allows the construction of cup-shaped molecules functionalized both at the upper and bottom rim. This feature makes the newly formed structures useful scaffolds for the development of supramolecular receptors.
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