The Beckmann rearrangement of cyclohexanone oxime to ε-caprolactam catalyzed by trifluoroacetic acid in aprotic solvents such as toluene, 1,2-dichloroethane, acetonitrile, benzonitrile, nitromethane and their mixtures is described. High yield and selectivity in ε-caprolactam have been observed. Data relative to cyclohexanone oxime protonation equilibrium, interaction of ε-caprolactam with the acid, solvent effect on reaction kinetics and apparent activation energy are given together with some thoughts on the reaction mechanism.
Organocatalyzed Beckmann rearrangement of cyclohexanone oxime by trifluoroacetic acid in aprotic solvent
RONCHIN, Lucio;VAVASORI, Andrea;BORTOLUZZI, Marco
2008-01-01
Abstract
The Beckmann rearrangement of cyclohexanone oxime to ε-caprolactam catalyzed by trifluoroacetic acid in aprotic solvents such as toluene, 1,2-dichloroethane, acetonitrile, benzonitrile, nitromethane and their mixtures is described. High yield and selectivity in ε-caprolactam have been observed. Data relative to cyclohexanone oxime protonation equilibrium, interaction of ε-caprolactam with the acid, solvent effect on reaction kinetics and apparent activation energy are given together with some thoughts on the reaction mechanism.File in questo prodotto:
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