The interactions of five dibenzofurans with the mitochondria from rat liver have been investigated. Results indicate that at low doses all dibenzofurans induce inhibition of ATP synthesis. The efficiency of ATP synthesis is measured from the ratio (R ) between the ADP-stimulated respiratory rate (State 3) and basal respiration (State 4). When R = 1, no ATP synthesis occurs. A comparison between the R values for all investigated dibenzofurans (PCDF) shows that the R values are in the same order of magnitude.

A study of the toxic effects of six dibenzofuranes in mitochondria from rat liver

MANENTE, Sabrina;PERIN, Guido;BRAGADIN, Marcantonio
1999

Abstract

The interactions of five dibenzofurans with the mitochondria from rat liver have been investigated. Results indicate that at low doses all dibenzofurans induce inhibition of ATP synthesis. The efficiency of ATP synthesis is measured from the ratio (R ) between the ADP-stimulated respiratory rate (State 3) and basal respiration (State 4). When R = 1, no ATP synthesis occurs. A comparison between the R values for all investigated dibenzofurans (PCDF) shows that the R values are in the same order of magnitude.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10278/16494
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