A catalytic system obtained by in situ mixing [RuCl2(benzene)]2 and (S)-BINAP has been tested in the asymmetric hydrogenation of various substrates. The best results have been obtained working in methanol: excellent optical purities were achieved in the reduction of substrates such as tiglic acid (83%), geraniol (97%) and methyl 3-oxobutanoate (95%). Some investigations on the nature of the catalyst have been carried out.
Asymmetric hydrogenation by an in situ prepared (S)-BINAP–Ru(II) catalytic system
MATTEOLI, Ugo;BEGHETTO, Valentina;SCRIVANTI, Alberto
1999-01-01
Abstract
A catalytic system obtained by in situ mixing [RuCl2(benzene)]2 and (S)-BINAP has been tested in the asymmetric hydrogenation of various substrates. The best results have been obtained working in methanol: excellent optical purities were achieved in the reduction of substrates such as tiglic acid (83%), geraniol (97%) and methyl 3-oxobutanoate (95%). Some investigations on the nature of the catalyst have been carried out.
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