A catalytic system obtained by in situ mixing [RuCl2(benzene)]2 and (S)-BINAP has been tested in the asymmetric hydrogenation of various substrates. The best results have been obtained working in methanol: excellent optical purities were achieved in the reduction of substrates such as tiglic acid (83%), geraniol (97%) and methyl 3-oxobutanoate (95%). Some investigations on the nature of the catalyst have been carried out.
|Data di pubblicazione:||1999|
|Titolo:||Asymmetric hydrogenation by an in situ prepared (S)-BINAP–Ru(II) catalytic system|
|Rivista:||JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S1381-1169(98)00235-0|
|Appare nelle tipologie:||2.1 Articolo su rivista |
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