A conjugate which is capable of specific binding to and inhibition of urokinase-type plasminogen activator (UPA) comprising a polypeptide molecule and a scaffold molecule, wherein said polypeptide molecule is attached to said scaffold molecule by at least three covalent bonds and wherein the inhibition constant (Ki) for said inhibitor is less than 500 nM.
Generation of a selective urokinase-type plasminogen activator (uPA) inhibitor based on a bicyclic peptide
Alessandro Angelini;
2011-01-01
Abstract
A conjugate which is capable of specific binding to and inhibition of urokinase-type plasminogen activator (UPA) comprising a polypeptide molecule and a scaffold molecule, wherein said polypeptide molecule is attached to said scaffold molecule by at least three covalent bonds and wherein the inhibition constant (Ki) for said inhibitor is less than 500 nM.
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