Sulfur and nitrogen (half-)mustard carbonate analogues are a new class of compounds, easily synthesized by methoxycarbonylation reaction of the parent alcohols with dialkyl carbonates. In this work, their reactivity as novel, green electrophiles is reported. Reactions have been conducted in autoclave conditions at high temperature (180°C), under pressure and in absence of any base, as well as, in neat at atmospheric pressure, lower temperature (150°C) and in the presence of a catalytic amount of a base. Several nucleophiles have been investigated resulting, in some cases, in unexpected compounds, i.e., six-membered heterocycle piperidine.
Mustard Carbonate analogues
ARICO', Fabio;TUNDO, Pietro
2013-01-01
Abstract
Sulfur and nitrogen (half-)mustard carbonate analogues are a new class of compounds, easily synthesized by methoxycarbonylation reaction of the parent alcohols with dialkyl carbonates. In this work, their reactivity as novel, green electrophiles is reported. Reactions have been conducted in autoclave conditions at high temperature (180°C), under pressure and in absence of any base, as well as, in neat at atmospheric pressure, lower temperature (150°C) and in the presence of a catalytic amount of a base. Several nucleophiles have been investigated resulting, in some cases, in unexpected compounds, i.e., six-membered heterocycle piperidine.File | Dimensione | Formato | |
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