Dibenzyl carbonate (DBzlC) has been used to benzylate phenylacetonitrile, benzyl phenylacetate and phenol. In refluxing N,N-dimethylformamide (DMF) as solvent, and in the presence of K,C03 phenol yielded benzyl phenyl ether and phenylacetonitrile the monobenzylated compound 2,3-diphenylpropionitrile. Likewise, in refluxing N,N-diethylformamide (DEF), benzyl phenyl acetate gave the benzyl 2,3-diphenylpropionate. Selectivity in mono-C-benzyl derivatives was 98-99% at a conversion up to 90%. Such unusually high selectivity is explained in terms of a mechanism involving, initially, carboxybenzylation followed by benzylation, rather than direct benzylation.

Selective mono-benzylation of methylene active compounds with dibenzyl carbonate: benzylation of phenol

SELVA, Maurizio;TUNDO, Pietro
1995-01-01

Abstract

Dibenzyl carbonate (DBzlC) has been used to benzylate phenylacetonitrile, benzyl phenylacetate and phenol. In refluxing N,N-dimethylformamide (DMF) as solvent, and in the presence of K,C03 phenol yielded benzyl phenyl ether and phenylacetonitrile the monobenzylated compound 2,3-diphenylpropionitrile. Likewise, in refluxing N,N-diethylformamide (DEF), benzyl phenyl acetate gave the benzyl 2,3-diphenylpropionate. Selectivity in mono-C-benzyl derivatives was 98-99% at a conversion up to 90%. Such unusually high selectivity is explained in terms of a mechanism involving, initially, carboxybenzylation followed by benzylation, rather than direct benzylation.
1995
15
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10278/32367
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